Archibald was the 4th boy of Sir Alfred Baring Garrod, a doctor at King's College Hospital, who discovered the abnormal uric acid metabolism associated with gout.

He was educated at Marlborough and Christ Church, Oxford University. He graduated sustaining an honours degree witharound natural science in 1880. He received farther medical step by step training at St. Bartholomew's Hospital in London. He spent many months of graduate survey at a Allgemeines Krankenhaus in Vienna in 1884-85. Around 1885 he found his BM & Mthe from either Oxford, & became a member of the Royal College of Physicians, London.

Across a next Xx years he served on the attending staff of many hospitals inside London: Marylebone General Dispensary, West London Hospital, St. Bartholomew's Hospital, a Great Ormond Street Hospital for Tykes, & Alexandra Hospital for Children by using Hip Disease.

He married Laura Elizabeth Smith inside 1886. It experienced Leash sons & the girl.

Garrod wwhen the advocator of research project as the foundatiin of medical practice, & published on a kind of diseases & topics throughout his career, including An Introduction to the Utilise of the Laryngoscope (1886) & The Treatise in Rheumatism & Rheumatoid Arthritis (1890). He helped encountered a Quarterly Journal of Medicine to provide a forum for extra fundamental the food and drug administration into the processes of disease. He helped edit the pedology school text, Diseases of Youngsters (1913), by owning F.E. Batten & Hugh Thursfield.

He developed an increasing interest within chemical pathology, & investigated urine chemistry as a reflection of systemic metabolism and disease. This locate, combined by owning a fresh understanding of Mendelian inheritance, evolved from an investigation of two or three families by owning an obscure & does'nt super unsafe disease (alkaptonuria) to the realization that a whole territory of mysterious diseases may exist when understood as inherited disease of metabolism.

Alkaptonuria occurs as uncommon hereditary disease of organic acid metabolism that is better known for the blackening of water from either yellowness to black to black when these are contaminated to the air. Inside late life, souls using this disease respond with arthritis characterized by deposition of brown pigment within joint cartilage and connective tissue. Garrod exposed a return system around many families, realized it followed an autosomal recessive pattern of inheritance, and postulated that it was from either the mutation inside the cistron for enzyme taking part in the metabolism of the class of compounds known as alkaptans. He published the Incidence of Alkaptonuria: a Survey withwithin Chemical Individuality in 1902.

Across a next decade he developed an understanding of the conceivable nature and severity of inherited disorder of metabolism. He formulated a "one gene, one enzyme" hypothesis & described a nature and severity of recessive inheritance of virtually all enzyme defects. Inside 1908, a core of this operate wwhen presented as a Croonian lectures to the Royal College of Physicians, entitled Inborn Errors of Metabolism & published a resulting season. Garrod expanded his metabolic studies to handle cystinuria, pentosuria, & albinism.

When you took a First World War Garrod served as medical advisor to the army, primarily within Malta. 2 of his tercet sons were flushed in a war & a third died when you took the neat influenza epidemic of 1919.

Witharound 1923 he summarized these studies in an expanded edition of his better known operate, [http://www.esp.org/books/garrod/inborn-errors/facsimile/| Inborn Errors of Metabolism]. When it became clearer that he got pioneered the recently field of medicine, Garrod was progressively honored within Engl& and overseas. He succeeded William Osler as Regius Professor of Medicine at Oxford. He was elected the Fellow of the Royal Society, was appointive to the Medical The food & drug administration Council, & was mass produced an honorary member of the U.s. Association of Physicians, and of the Artzlicher Vereinside in Munich. He received honorary degrees from either a universities of Aberdeen, Dublin, Glasgow, Malta, & Padua. Around 1935 he was awarded a Gold Medal of the Royal Society of Medicine.

He died at the Cambridge at home of his girl fallowing a brief unwellness inside 1936.

Publications
The Nebulae: The Fragment of Astronomic History (Oxford, 1882) An Introduction to the Have of the Laryngoscope (1886) A Treatise in Rheumatism & Rheumatoid Arthritis (1890) A Vade mecum of Medical Pathology, for the Have of Students in the Museum of St Bartholomew's Hospital (1894), by owning Sir W.P. Herringham & W.J. Gow A Treatise in Cholelithiasis, Bernhard Naunyn, translated by Garrod (London, 1896) Clinical Diagnosing, Rudolf Von Jaksch, edited by Garrod (London, Fifth ed., 1905) Inborn Errors of Metabolism (1909), 2nd edition 1923 Diseases of Toddlers (1913), sustaining F.E. Batten & Hugh Thursfield The Inborn Factors of Disease (1931)